Percocet 7,5/500 mg

Percocet 7.5/500mg – High-Dose Acetaminophen Opioid Combination
(Now Withdrawn from US Market – Safety Alert)

⚠️ Critical Prescribing Notice:

This formulation was discontinued in 2011 as part of the FDA-mandated acetaminophen dose reduction initiative to prevent liver toxicity. The current maximum allowable APAP in combo opioids is 325mg per unit dose.

If You Have This Medication:

1. STOP USE IMMEDIATELY – Risk of accidental hepatotoxicity

2. Contact Your Pharmacist – For proper disposal

3. Ask Your Doctor About Alternatives:

   • Percocet 7.5/325mg (current standard)

   • Oxycodone IR 7.5mg + separate APAP

   • Non-APAP options (e.g., oxycodone alone)

Why This Formula Was Dangerous:

• 500mg APAP per tablet → Exceeds 4g/day limit with just 8 doses
• Unintentional overdose risk when combined with other APAP products
• No therapeutic advantage over 325mg formulations

Current Guidelines for Equivalent Pain Control:

Option 1:
• Percocet 7.5/325mg 1-2 tabs q6h
• Max: 6 tabs/day (1,950mg APAP)

Option 2:
• Oxycodone 7.5mg IR + Tylenol 325mg PRN
• Allows better APAP monitoring

Option 3 (Chronic Pain):
• Oxycodone ER + APAP-free rescue med

FDA-Approved Alternatives:

Patient Advisory:

If you were previously prescribed 7.5/500mg:
✓ Request liver function tests
✓ Review all medications for hidden APAP
✓ Obtain naloxone rescue kit if continuing opioids

Pharmacist Note:

All legacy 7.5/500mg prescriptions should be:
❌ Rejected (invalid dosage form)
❌ Reported to state PDMP if encountered
❌ Replaced with safer alternatives

Consult pain management specialists for therapeutic alternatives tailored to your needs.