Hydrocodone 10/500mg

Therapeutic Profile (Historical Use)

• Kontrolovaná látka podľa prílohy II (High potential for abuse/dependence)

• Composition:

  • Hydrocodone 10mg (opioid agonist)

  • Acetaminophen 500mg (non-opioid analgesic)

• Nástup: ~30 minutes

• Trvanie: 4–6 hours

Reason for Discontinuation:

• Acetaminophen Toxicity Risk:

  • 6 tablets = 3,000mg APAP (daily max for chronic use)

  • 8 tablets = 4,000mg APAP (acute liver failure risk)

• FDA Mandate (2011): All opioid/APAP combos limited to ≤325mg APAP per dose

Modern Alternatives:

Safety Considerations:

✔ Never exceed 3,000mg APAP/day (chronic) or 4,000mg/day (acute)
✔ Avoid alcohol (increases liver toxicity risk)
✔ Watch for hidden APAP in cold/flu medications

If You Encounter 10/500mg Tablets:

• Do NOT use – May be counterfeit/expired

• Switch to current formulations (e.g., Norco 10/325mg)

• Consult a doctor for proper pain management

Available Alternatives:

• For short-term pain: Norco 10/325mg

• For chronic pain: Hysingla ER (APAP-free)

• Non-opioid options: NSAIDs, gabapentin, physical therapy

Prescribing Note:

• Hydrocodone combos are Schedule II (strict regulations apply)

• Naloxone co-prescription odporúčané