Percocet 7.5/325mg

Percocet 7.5/325mg – Balanced Opioid Analgesia for Moderate to Severe Pain

Intermediate-strength oxycodone/APAP combination for controlled pain relief

Therapeutic Profile

• Oxycodone HCl: 7.5mg (Schedule II opioid agonist)

• Acetaminophen: 325mg (non-opioid analgesic)

• Duration: 4–6 hours of pain control

• Tmax: 1–1.5 hours post-dose

Clinical Applications

✔ Postoperative pain (e.g., dental surgery, minor orthopedic procedures)
✔ Acute injury management (fractures, severe sprains)
✔ Breakthrough cancer pain (adjunct to long-acting opioids)
✔ Short-term severe pain when NSAIDs are contraindicated

Dosing Guidelines

• Adults (opioid-tolerant): 1 tab q4–6h PRN pain

• Max Daily APAP: ≤3,250mg (≤10 tabs/24hr)

• Opioid-Naive Patients: Start with 5/325mg first

• Renal Impairment: Consider reduced frequency

Risk Mitigation Strategies

⚠️ ABUSE DETERRENT:

• Tablets are crush-resistant (but not abuse-proof)

• Tinted and imprinted for identification

⚠️ MANDATORY MONITORING:

• Assess pain/function at each follow-up

• Check state PDMP before prescribing

• Urine drug screening recommended

⚠️ SAFETY ALERTS:

• Respiratory depression risk (avoid with benzos/alcohol)

• APAP hepatotoxicity (no additional acetaminophen)

• Opioid-induced constipation (stimulant laxatives advised)

Comparative Advantages

→ Stronger than hydrocodone 5/325mg
→ Less sedating than morphine IR
→ More versatile than codeine combinations
→ Lower APAP load than legacy 10/500 formulations

Patient Counseling Points

• “Take only when severe pain occurs”

• “Never share with others”

• “Store locked away from children/pets”

• “Report dizziness or slow breathing immediately”

• “Use stool softeners preventatively”

Prescribing Considerations

▸ First-line for moderate-severe acute pain
▸ Avoid in chronic pain without specialist consultation
▸ Requires Risk Evaluation and Mitigation Strategy (REMS) compliance
▸ Preferred over higher doses for elderly/renal patients

Available as:

• Peach oval tablets (brand)

• White round generics

• Unit-dose packaging for hospitals