Oxykodon 10 mg

Oxycodone HCl 10mg – Controlled Opioid Analgesia for Moderate to Severe Pain
(Available in Immediate & Extended-Release Formulations)

Terapeutický profil

• Schedule II controlled substance
• Onset/Duration:

• Immediate-Release (IR): 15-30min onset, 4-6hr duration

• Extended-Release (ER): 1-2hr onset, 12hr duration
  • METABOLISM: Hepatic (CYP3A4/2D6)

Klinické indikace

✔ Acute post-surgical pain (IR only)
✔ Breakthrough cancer pain (with ER baseline)
✔ Severe injury trauma (short-term IR use)
✔ Chronic pain (ER only for opioid-tolerant patients)

Dávkování

For OPIOID-NAÏVE Patients (IR only):

• Start with 5mg q4-6h PRN

• Titrate cautiously → max 10mg/dose

Pro pacienty s tolerancí na opioidy:

• ER: 10mg q12h (must confirm ≥20mg MEDD baseline)

• IR: 10mg q4-6h PRN breakthrough pain

Critical Administration Notes:

• ER tablets: Swallow whole – never crush/chew

• IR tablets: May be split for dose adjustment

• Food effect: High-fat meals ↑ ER absorption 25%

Abuse-Deterrent Formulations

• ER versions: OxyContin OP, Xtampza ER

• IR versions: Oxaydo (nasal abuse-resistant)

Varování černé skříňky

⚠️ ADDICTION/OVERDOSE RISK
⚠️ ŽIVOT OHROŽUJÍCÍ RESPIRAČNÍ DEPRESE
⚠️ NEONATAL WITHDRAWAL

Safety Protocols

• Naloxone co-prescription požadovaný
• PDMP review před každým předpisem
• Urine drug screening for chronic use
• Skladování: Locked container mandatory

Identifikace produktu

IR Tablets:

• Round white (generic)

• Imprint varies by manufacturer

ER Tablets:

• OxyContin 10mg: Gray “OP” on one side

• Xtampza ER: Capsule form