Oxykodon 20 mg

Oxycodone HCl 20mg – High-Dose Opioid for Severe Pain Management
(Extended-Release Formulation – For Opioid-Tolerant Patients Only)

⚠️ Critical Safety Alert

• NOT FOR OPIOID-NAÏVE PATIENTS

• Minimum Requirement: ≥40mg MEDD (morphine equivalent daily dose) for ≥1 week

• ABSOLUTELY NEVER crush, chew, or dissolve

Terapeutický profil

• Schedule II controlled substance (DEA)
• Trvání: 12hodinové řízené uvolňování
• Vrcholový efekt: 4-5 hours post-dose
• Metabolismus: Liver (CYP3A4/2D6 dependent)

FDA-Approved Indications

✔ Around-the-clock cancer pain
✔ Chronic severe pain (with documented tolerance)
✔ Palliative care when lower doses fail

Dávkovací protokol

• Conversion from Other Opioids:
  20mg oxycodone ER q12h = 60mg oral morphine/day

• Porucha funkce ledvin:
  Reduce dose by 50% if CrCl <30mL/min

• Hepatic Caution:
  Start with 50% dose in cirrhosis

Abuse-Deterrent Features

• Hardened Tablet Matrix (resists crushing)

• Gel-Forming Technology if manipulated

• Brand Examples: OxyContin OP, Xtampza ER

Varování černé skříňky

🛑 VYSOKÝ POTENCIÁL ZÁVISLOSTI – Abuse may cause overdose/death
🛑 ŽIVOT OHROŽUJÍCÍ RESPIRAČNÍ DEPRESE (especially with CNS depressants)
🛑 ACCIDENTAL INGESTION – One tablet can kill a child

Prescribing Requirements

• Documented Opioid Tolerance
• Pain Management Agreement signed
• Současný předpis s naloxonem mandatory
• Monthly PDMP Checks

Identifikace produktu

• OxyContin OP 20mg:
  • Round, pink tablets
  • “OP” on one side, “20” on reverse

• Generic ER:
  • Varies by manufacturer (all must have FDA-approved AD properties)

Clinical Protocol:

1. Confirm opioid tolerance

2. Calculate prior 72-hour MEDD

3. Start at 50-75% conversion dose

4. Reassess every 3-7 days